Calcium dyshomeostasis in the course of disease in individual patients with Alzheimer´s dementia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F03%3A00000318" target="_blank" >RIV/00023752:_____/03:00000318 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Calcium dyshomeostasis in the course of disease in individual patients with Alzheimer´s dementia
Original language description
Destabilization of intracellular calcium homeostasis in neurons has been implicated in the pathogenesis of Alzheimer´s dementia (AD). In this study the disturbed calcium homeostasis was examined in platelets of AD patients during the course of the disease and on individual basis. There were no significant differences in calcium homeostasis between mild, moderate and severe stages of AD (n=46), but significant changes were found in all AD stages compared to age-matched nondemented control subjects (n=18). In individual, long term monitored AD patients, the percentage of increase in platelet free intracellular calcium level, in the presence of 1mM calcium in the incubation medium above the basal value, decreased with the progression of the disease in allcases (n=6).
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
New Trends in Alzheimer and Parkinson Related Disorders
ISBN
88-7587-023-3
Number of pages of the result
4
Pages from-to
53-56
Number of pages of the book
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Publisher name
Monduzzi Editore
Place of publication
Bologna
UT code for WoS chapter
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