Viral infection, glutamatergic deficit and behavioral changes in animal model of schizophrenia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F03%3A00000323" target="_blank" >RIV/00023752:_____/03:00000323 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Viral infection, glutamatergic deficit and behavioral changes in animal model of schizophrenia

Original language description

Retroviruses can disrupt brain development, cause neuronal death and induce behavioural changes and therefore they have been proposed to play a role in the etiology of schizophrenia. Quinolinic acid (QUIN), released from retrovirus-infected brain macrophages and microglia, might be responsible, at least in part, for most of the proposed alterations. Intracerebroventricular infusion of QUIN to rat pups did cause a neuronal damage and evoked a subsequent diminution of the specific membrane binding of glutamate and changed their exploratory and acoustic startle activities in early adulthood. The changes were modified (potentiated) by increased levels of brain dopamine and inhibited by haloperidol and clozapine. Our present data suggest that increased levels of QUIN in neonatal rat brain can induce changes in the brain development and function have effects that exhibit some similarities to human schizophrenia.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2003

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Psychiatrie

ISSN

1211-7579

e-ISSN

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Volume of the periodical

7

Issue of the periodical within the volume

Suppl. 2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

3

Pages from-to

128-130

UT code for WoS article

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EID of the result in the Scopus database

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