Avidity of antibodies against tau protein in patients with multiple sclerosis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F09%3A00001018" target="_blank" >RIV/00023752:_____/09:00001018 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/09:5085
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Avidity of antibodies against tau protein in patients with multiple sclerosis
Original language description
Background: The low-molecular-weight tau protein belongs to the microtubule-associated proteins abundantly present in the central nervous system and expressed predominantly in axons (1). The function of these phosphoproteins is associated with the neuronal cytoskeleton. Tau stabilizes microtubules and promotes their polymerization (1). Some neurological diseases of the CNS include axonal injury. Multiple sclerosis (MS) is one of the disorders in whose pathogenesis the axonal damage is involved (2). Several cytoskeletal structures have been explored to reflect this event. Tubulin, neurofilaments, actin or tau proteins were examined as markers of the axonal damage (3, 4). During this process cytoskeletal structures are released into the extracellular environment, where the synthesis of specific antibodies may be induced (5, 6). It was observed that immunization of mice by the recombinant tau protein induced the synthesis of anti-tau antibodies. Moreover, these specific anti-tau antibodie
Czech name
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Czech description
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Project
<a href="/en/project/NS10369" target="_blank" >NS10369: Use of neurocytoskeletal proteins and antibodies against them for diagnosis of Alzheimer´s disease</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
From Pathogenesis to Therapy of Autoimmune Diseases. Autoantigens, Autoantibodies, Autoimmunity
ISBN
978-3-89967-579-5
ISSN
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e-ISSN
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Number of pages
3
Pages from-to
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Publisher name
Pabst Science Publishers
Place of publication
Dresden
Event location
Dresden
Event date
Sep 2, 2009
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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