Protein tau-mediated effects on rat hippocampal choline transporters CHT1 and tau-amyloid beta interactions

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F13%3A43914467" target="_blank" >RIV/00023752:_____/13:43914467 - isvavai.cz</a>

Result on the web

<a href="http://link.springer.com/article/10.1007%2Fs11064-013-1101-5" target="_blank" >http://link.springer.com/article/10.1007%2Fs11064-013-1101-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11064-013-1101-5" target="_blank" >10.1007/s11064-013-1101-5</a>

Result language

angličtina

Original language name

Protein tau-mediated effects on rat hippocampal choline transporters CHT1 and tau-amyloid beta interactions

Original language description

Intracellular tau protein, when released extracellularly upon neuron degeneration, could evoke direct toxic effects on the cholinergic neurotransmitter system through muscarinic receptors and thus contribute to the pathogenesis of Alzheimer's disease. Weevaluated the in vitro effects of six naturally occurring monomeric tau isoforms on rat hippocampal synaptosomal choline transporters CHT1. Some tau isoforms at nM concentrations inhibited choline transport in a dose- and time-dependent saturable manner(352 = 441 > 410 = 383 > 381 = 412) and effects were associated with changes in the Michaelis constant rather than in maximal velocity. Moreover, the actions of tau 352/441 were not influenced by previous depolarisation of synaptosomes or by previous depletion of membrane cholesterol. Results obtained on CHT1 transporters from cholesterol-depleted synaptosomes supported interactions between amyloid beta 1-40 and tau 352. It seems that protein tau, similar to amyloid beta, can contribute

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neurochemical Research

ISSN

0364-3190

e-ISSN

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Volume of the periodical

38

Issue of the periodical within the volume

9

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

1949-1959

UT code for WoS article

000322722700021

EID of the result in the Scopus database

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