Protein ?-mediated effects on rat hippocampal choline transporters CHT1 and ?-amyloid ? interactions
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985882%3A_____%2F13%3A00396521" target="_blank" >RIV/67985882:_____/13:00396521 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s11064-013-1101-5" target="_blank" >http://dx.doi.org/10.1007/s11064-013-1101-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11064-013-1101-5" target="_blank" >10.1007/s11064-013-1101-5</a>
Alternative languages
Result language
angličtina
Original language name
Protein ?-mediated effects on rat hippocampal choline transporters CHT1 and ?-amyloid ? interactions
Original language description
It is suggested that intracellular tau protein (?), when released extracellularly upon neuron degeneration, could evoke direct toxic effects on the cholinergic neurotransmitter system through muscarinic receptors and thus contribute to the pathogenesis of Alzheimer's disease. In this study, we evaluated the in vitro effects of six naturally occurring monomeric ? isoforms on rat hippocampal synaptosomal choline transporters CHT1 (large transmembrane proteins associated with high-affinity choline transport and vulnerable to actions of amyloid ? peptides (A?) applied in vitro or in vivo). Some ? isoforms at nM concentrations inhibited choline transport in a dose- and time-dependent saturable manner (352 = 441 > 410 = 383 > 381 = 412) and effects were associated with changes in the Michaelis constant rather than in maximal velocity. Moreover, the actions of ? 352/441 were not influenced by previous depolarisation of synaptosomes or by previous depletion of membrane cholesterol. Specific bi
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
JA - Electronics and optoelectronics
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neurochemical Research
ISSN
0364-3190
e-ISSN
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Volume of the periodical
38
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
1949-1959
UT code for WoS article
000322722700021
EID of the result in the Scopus database
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