Beta amyloid protein and plant cysteine proteases influence the (3H)hemicholinium-3 binding site in vitro in rat hippocampus.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F99%3A00000003" target="_blank" >RIV/00023752:_____/99:00000003 - isvavai.cz</a>

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Beta amyloid protein and plant cysteine proteases influence the (3H)hemicholinium-3 binding site in vitro in rat hippocampus.

Original language description

In vitro effects of beta amyloid peptide 1-40 and of two proteases bromelain and papain were evaluated on hippocampal synaptosomes of 3-month old Wistar rats. Our experiments suggest that 100 nM amyloid eliminates depolarization effects. However, no changes were measured under basal conditions. Proteases influence the choline uptake (bromelain) or the bindig of uptake inhibitor (papain) under both basal and stimulated conditions. The synaptosomal transport previously inhibited by amyloid is more sensitive to the effects of bromelain and papain.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

—

Project

<a href="/en/project/GA305%2F99%2F1317" target="_blank" >GA305/99/1317: Functional changes of capillaries isolated from brain tissue under normal and pathological ageing, effects of plant proteases</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

1999

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

—

Volume of the periodical

48

Issue of the periodical within the volume

suppl.1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

1

Pages from-to

—

UT code for WoS article

—

EID of the result in the Scopus database

—