Risk of mental illness in offspring of parents with schizophrenia, bipolar disorder, and major depressive disorder: A meta-analysis of family high-risk studies

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F14%3A43914534" target="_blank" >RIV/00023752:_____/14:43914534 - isvavai.cz</a>

Result on the web

<a href="http://schizophreniabulletin.oxfordjournals.org/content/40/1/28" target="_blank" >http://schizophreniabulletin.oxfordjournals.org/content/40/1/28</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/schbul/sbt114" target="_blank" >10.1093/schbul/sbt114</a>

Result language

angličtina

Original language name

Risk of mental illness in offspring of parents with schizophrenia, bipolar disorder, and major depressive disorder: A meta-analysis of family high-risk studies

Original language description

Objective: Offspring of parents with severe mental illness (SMI; schizophrenia, bipolar disorder, major depressive disorder) are at an increased risk of developing mental illness. We aimed to quantify the risk of mental disorders in offspring and determine whether increased risk extends beyond the disorder present in the parent. Method: Meta-analyses of absolute and relative rates of mental disorders in offspring of parents with schizophrenia, bipolar disorder, or depression in family high-risk studiespublished by December 2012. Results: We included 33 studies with 3863 offspring of parents with SMI and 3158 control offspring. Offspring of parents with SMI had a 32% probability of developing SMI (95% CI: 24%-42%) by adulthood (age > 20). This risk wasmore than twice that of control offspring (risk ratio [RR] 2.52; 95% CI 2.08-3.06, P <.001). High-risk offspring had a significantly increased rate of the disorder present in the parent (RR = 3.59; 95% CI: 2.57-5.02, P <.001) and of othe

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FL - Psychiatry, sexology

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Schizophrenia Bulletin

ISSN

0586-7614

e-ISSN

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Volume of the periodical

40

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

28-38

UT code for WoS article

000329905200008

EID of the result in the Scopus database

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