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Levels of 17?-hydroxysteroid dehydrogenase type 10 in cerebrospinal fluid of people with mild cognitive impairment and various types of dementias

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F15%3A43914762" target="_blank" >RIV/00023752:_____/15:43914762 - isvavai.cz</a>

  • Result on the web

    <a href="http://content.iospress.com/articles/journal-of-alzheimers-disease/jad142898" target="_blank" >http://content.iospress.com/articles/journal-of-alzheimers-disease/jad142898</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3233/JAD-142898" target="_blank" >10.3233/JAD-142898</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Levels of 17?-hydroxysteroid dehydrogenase type 10 in cerebrospinal fluid of people with mild cognitive impairment and various types of dementias

  • Original language description

    Background: Overexpression of the mitochondrial enzyme 17?-hydroxysteroid dehydrogenase type 10 (17?-HSD10, which is also known as the intracellular amyloid-? peptide (A?) binding protein) is observed in cortical or hippocampal regions of patients with Alzheimer's disease (AD). It appears that 17?-HSD10 may play a role in the pathogenesis of AD. Objective: We investigated the possibility that levels of 17?-HSD10 in cerebrospinal fluid could be a prospective biomarker of AD. Methods: We estimated the enzyme levels in 161 people (15 non-demented controls, 52 people with mild cognitive impairment (MCI), 35 people with probable AD, or 59 people with other types of dementia) and compared them with those of A?1 - 42, tau, and phospho-tau. Results: We found significantly higher levels of 17?-HSD10 in people with MCI due to AD (to 109.9% ), with AD (to 120.0% ), or with other types of dementia (to 110.9% ) when compared to the control group. The sensitivity of the new biomarker to AD was 80.0%

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FH - Neurology, neuro-surgery, nuero-sciences

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Alzheimer's Disease

  • ISSN

    1387-2877

  • e-ISSN

  • Volume of the periodical

    48

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    10

  • Pages from-to

    105-114

  • UT code for WoS article

    000360931700010

  • EID of the result in the Scopus database

    2-s2.0-84940995512