Levels of 17?-hydroxysteroid dehydrogenase type 10 in cerebrospinal fluid of people with mild cognitive impairment and various types of dementias

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F15%3A43914762" target="_blank" >RIV/00023752:_____/15:43914762 - isvavai.cz</a>
Result on the web
<a href="http://content.iospress.com/articles/journal-of-alzheimers-disease/jad142898" target="_blank" >http://content.iospress.com/articles/journal-of-alzheimers-disease/jad142898</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3233/JAD-142898" target="_blank" >10.3233/JAD-142898</a>

Result language
angličtina
Original language name
Levels of 17?-hydroxysteroid dehydrogenase type 10 in cerebrospinal fluid of people with mild cognitive impairment and various types of dementias
Original language description
Background: Overexpression of the mitochondrial enzyme 17?-hydroxysteroid dehydrogenase type 10 (17?-HSD10, which is also known as the intracellular amyloid-? peptide (A?) binding protein) is observed in cortical or hippocampal regions of patients with Alzheimer's disease (AD). It appears that 17?-HSD10 may play a role in the pathogenesis of AD. Objective: We investigated the possibility that levels of 17?-HSD10 in cerebrospinal fluid could be a prospective biomarker of AD. Methods: We estimated the enzyme levels in 161 people (15 non-demented controls, 52 people with mild cognitive impairment (MCI), 35 people with probable AD, or 59 people with other types of dementia) and compared them with those of A?1 - 42, tau, and phospho-tau. Results: We found significantly higher levels of 17?-HSD10 in people with MCI due to AD (to 109.9% ), with AD (to 120.0% ), or with other types of dementia (to 110.9% ) when compared to the control group. The sensitivity of the new biomarker to AD was 80.0%
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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