Interactions between Amyloid-beta and Tau in Cerebrospinal Fluid of People with Mild Cognitive Impairment and Alzheimer's Disease

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F14%3A10292989" target="_blank" >RIV/00064203:_____/14:10292989 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/14:00061045 RIV/00216208:11130/14:10292989 RIV/00023752:_____/14:43914642
Result on the web
<a href="http://dx.doi.org/10.3233/JAD-132393" target="_blank" >http://dx.doi.org/10.3233/JAD-132393</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3233/JAD-132393" target="_blank" >10.3233/JAD-132393</a>

Result language
angličtina
Original language name
Interactions between Amyloid-beta and Tau in Cerebrospinal Fluid of People with Mild Cognitive Impairment and Alzheimer's Disease
Original language description
Background: Despite the physiological sequestration of amyloid-beta (A beta) peptides by various carriers, interactions between peptides and protein tau appear to be pathological and involved in the development of Alzheimer's disease (AD). A recent studyreported increased A beta-tau interactions in the neurons of AD patients. Objective: We investigated the possibility that levels of A beta-tau complexes in cerebrospinal fluid could be a prospective biomarker of AD, with greater sensitivity and specificity than A beta(1-42), tau, or phospho-tau individually. Methods: By means of ELISA, we estimated levels of the complexes in 161 people (non-demented controls, people with mild cognitive impairment (MCI), probable AD or other types of dementia). Results:We found significant reductions in levels in people with MCI due to AD (down to 84.5%) or with AD (down to 80.5%) but not in other types of dementia. The sensitivity of the new biomarker to AD was 68.6%, the specificity 73.3% (compared t
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)