Autopsy-diagnosed neurodegenerative dementia cases support the use of cerebrospinal fluid protein biomarkers in the diagnostic work-up

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064190%3A_____%2F21%3AN0000056" target="_blank" >RIV/00064190:_____/21:N0000056 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/21:43921592 RIV/00216208:11110/21:10428063 RIV/00064165:_____/21:10428063 RIV/00064173:_____/21:N0000141

Result on the web

<a href="http://dx.doi.org/10.1038/s41598-021-90366-5" target="_blank" >http://dx.doi.org/10.1038/s41598-021-90366-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-021-90366-5" target="_blank" >10.1038/s41598-021-90366-5</a>

Result language

angličtina

Original language name

Autopsy-diagnosed neurodegenerative dementia cases support the use of cerebrospinal fluid protein biomarkers in the diagnostic work-up

Original language description

Various proteins play a decisive role in the pathology of different neurodegenerative diseases. Nonetheless, most of these proteins can only be detected during a neuropathological assessment, although some non-specific biomarkers are routinely tested for in the cerebrospinal fluid (CSF) as a part of the differential diagnosis of dementia. In antemortem CSF samples from 117 patients with different types of neuropathologically confirmed neurodegenerative disease with dementia, we assessed total-tau (t-tau), phosphorylated-tau (181P) (p-tau), amyloid-beta (1-42) (A beta 42), TAR DNA binding protein (TDP)-43, progranulin (PGRN), and neurofilament light (NfL) chain levels, and positivity of protein 14-3-3. We found t-tau levels and the t-tau/p-tau ratios were significantly higher in prion diseases compared to the other neurodegenerative diseases. Statistically significant differences in the t-tau/A beta 42 ratio predominantly corresponded to t-tau levels in prion diseases and A beta 42 levels in AD. TDP-43 levels were significantly lower in prion diseases. Additionally, the TDP-43/A beta 42 ratio was better able to distinguish Alzheimer's disease from other neurodegenerative diseases compared to using A beta 42 alone. In frontotemporal lobar degeneration, PRGN levels were significantly higher in comparison to other neurodegenerative diseases. There is an increasing need for biomarkers suitable for diagnostic workups for neurodegenerative diseases. It appears that adding TDP-43 and PGRN to the testing panel for neurodegenerative diseases could improve the resolution of differential diagnoses.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

SCIENTIFIC REPORTS

ISSN

2045-2322

e-ISSN

—

Volume of the periodical

11

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

Article Number 10837

UT code for WoS article

000659129600007

EID of the result in the Scopus database

2-s2.0-85106878917