Sex differences and serotonergic mechanisms in the behavioural effects of psilocin

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F16%3A43914800" target="_blank" >RIV/00023752:_____/16:43914800 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/16:43910988

Result on the web

<a href="http://journals.lww.com/behaviouralpharm/Abstract/2016/06000/Sex_differences_and_serotonergic_mechanisms_in_the.1.aspx" target="_blank" >http://journals.lww.com/behaviouralpharm/Abstract/2016/06000/Sex_differences_and_serotonergic_mechanisms_in_the.1.aspx</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/FBP.0000000000000198" target="_blank" >10.1097/FBP.0000000000000198</a>

Result language

angličtina

Original language name

Sex differences and serotonergic mechanisms in the behavioural effects of psilocin

Original language description

Psilocybin has recently attracted a great deal of attention as a clinical research and therapeutic tool. The aim of this paper is to bridge two major knowledge gaps regarding its behavioural pharmacology i.e. sex differences and the underlying receptor mechanisms. We used psilocin (0.25, 1 and 4 mg/kg), an active metabolite of psilocybin, in two behavioural paradigms - the open field test and the test of prepulse inhibition (PPI) of acoustic startle reaction. Sex differences were evaluated with respect to the phase of the female cycle. The contribution of serotonin receptors in the behavioural action was tested in male rats with selective serotonin receptor antagonists: 5-HT1A receptor antagonist (WAY100635 1 mg/kg), 5-HT2A receptor antagonist (MDL100907 0.5 mg/kg), 5-HT2B receptor antagonist (SB215505 1 mg/kg) and 5-HT2C receptor antagonist (SB242084 1 mg/kg). Psilocin induced dose dependent inhibition of locomotion and suppression of normal behaviour of rats (behavioural serotonin syndrome, impaired PPI). The effects were most pronounced in male rats, female rats were affected by psilocin treatment to a lesser degree. The inhibition of locomotion was normalized by 5-HT1A and 5-HT2B/C antagonists; however PPI was not affected significantly by antagonists used. Our findings highlight an important issue of sex specific reactions to psilocin and that apart from 5-HT2A mediated effects 5-HT1A and 5-HT2C/B receptors also play an important role. These findings have further implications for recent clinical trials.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FL - Psychiatry, sexology

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Behavioural Pharmacology

ISSN

0955-8810

e-ISSN

—

Volume of the periodical

27

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

309-320

UT code for WoS article

000375627500001

EID of the result in the Scopus database

2-s2.0-84965046020