Mescaline-induced behavioral alterations are mediated by 5-HT2A and 5-HT2C receptors in rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F24%3A43921389" target="_blank" >RIV/00023752:_____/24:43921389 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/24:43927742
Result on the web
<a href="https://www.sciencedirect.com/science/article/abs/pii/S0091305724001977" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0091305724001977</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.pbb.2024.173903" target="_blank" >10.1016/j.pbb.2024.173903</a>
Alternative languages
Result language
angličtina
Original language name
Mescaline-induced behavioral alterations are mediated by 5-HT2A and 5-HT2C receptors in rats
Original language description
Rationale: Mescaline is a classical psychedelic compound with a phenylethylamine structure that primarily acts on serotonin 5-HT2A/C receptors, but also binds to 5-HT1A and 5-HT2B receptors. Despite being the first psychedelic ever isolated and synthesized, the precise role of different serotonin receptor subtypes in its behavioral pharmacology is not fully understood.Objectives: In this study, we aimed to investigate how selective antagonists of 5-HT2A, 5-HT2B, 5-HT2C, and 5-HT1A receptors affect the behavioral changes induced by subcutaneous administration of mescaline (at doses of 10, 20, and 100 mg/kg) in rats.Methods: We used adult male Wistar rats in all our experiments. We evaluated locomotor activity using the open field test, and assessed sensorimotor gating deficits by measuring prepulse inhibition (PPI) of acoustic startle reaction (ASR).Results: While the highest dose of mescaline induced hyperlocomotion (p < 0.001), which almost all the other antagonists reversed (p < 0.05–0.001), the PPI deficits were selectively normalized by the 5-HT2A antagonist (p < 0.05–0.01). The 5-HT2C antagonist partially reversed the small PPI deficit induced by lower doses of mescaline (p = 0.0017).Conclusion: Our findings suggest that mescaline-induced changes in behavior are primarily mediated by the 5-HT2A receptor subtype, with less pronounced contributions from the 5-HT2C receptor. The other antagonists had limited effects.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pharmacology Biochemistry and Behavior
ISSN
0091-3057
e-ISSN
1873-5177
Volume of the periodical
245
Issue of the periodical within the volume
"Article number: 173903"
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
1-8
UT code for WoS article
001409048600001
EID of the result in the Scopus database
2-s2.0-85209389426