Virtual spatial navigation tests based on animal research: spatial cognition deficit in first episodes of schizophrenia
The result's identifiers
Result code in IS VaVaI
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Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Virtual spatial navigation tests based on animal research: spatial cognition deficit in first episodes of schizophrenia
Original language description
The impairment of cognitive functions represents a characteristic manifestation in schizophrenia and related psychotic disorders, together with positive and negative symptoms. Cognitive symptoms offer very useful methodological approach for comparative studies in schizophrenia research. Both animal models of schizophrenia and schizophrenia patients have demonstrated behavioral changes in several spatial navigation tasks; assessment of spatial cognition can be therefore applied in comparative studies. In order to demonstrate the deficit of spatial cognition in schizophrenia, and to test the validity of pharmacological animal models of schizophrenia, we designed two virtual navigation tasks inspired by previous animal research: the virtual Morris water maze and the virtual Carousel maze. Both virtual tests consisting of four phases have been tested in a group of 30 first episode schizophrenia patients and a group of healthy volunteers matched for age, sex and education. In both tests, subjects were required to navigate towards several hidden goal positions placed on the floor of an enclosed stable arena or a rotating arena. Data obtained using these virtual tests show a decline in the cognitive performance of schizophrenia patients in comparison to matched healthy volunteers. Our findings support the validity of the animal model of cognitive deficit in schizophrenia and the presence of impaired cognitive functions in schizophrenia patients.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
AN - Psychology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Recent Advances on Using Virtual Reality Technologies for Rehabilitation
ISBN
978-1-63484-027-9
Number of pages of the result
12
Pages from-to
111-122
Number of pages of the book
196
Publisher name
Nova Science Publishers
Place of publication
New York
UT code for WoS chapter
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