Dizocilpine (MK-801) impairs learning in the active place avoidance task but has no effect on the performance during task/context alternation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F16%3A43914981" target="_blank" >RIV/00023752:_____/16:43914981 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/16:00458400 RIV/00216208:11110/16:10326139

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S0166432816301450" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0166432816301450</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bbr.2016.03.020" target="_blank" >10.1016/j.bbr.2016.03.020</a>

Result language

angličtina

Original language name

Dizocilpine (MK-801) impairs learning in the active place avoidance task but has no effect on the performance during task/context alternation

Original language description

The prevention of engram interference, pattern separation, flexibility, cognitive coordination and spatial navigation are usually studied separately at the behavioral level. Impairment in executive functions is often observed in patients suffering from schizophrenia. We have designed a protocol for assessing these functions all together as behavioral separation. This protocol is based on alternated or sequential training in two tasks testing different hippocampal functions (the Morris water maze and active place avoidance), and alternated or sequential training in two similar environments of the active place avoidance task. In Experiment 1, we tested, in adult rats, whether the performance in two different spatial tasks was affected by their order in sequential learning, or by their day-to-day alternation. In Experiment 2, rats learned to solve the active place avoidance task in two environments either alternately or sequentially. We found that rats are able to acquire both tasks and to discriminate both similar contexts without obvious problems regardless of the order or the alternation. We used two groups of rats, controls and a rat model of psychosis induced by a subchronic intraperitoneal application of 0.08 mg/kg of dizocilpine (MK-801), a non-competitive antagonist of NMDA receptors. Dizocilpine had no selective effect on parallel/sequential learning of tasks/contexts. However, it caused hyperlocomotion and a significant deficit in learning in the active place avoidance task regardless of the task alternation. Cognitive coordination tested by this task is probably more sensitive to dizocilpine than spatial orientation because no hyperactivity or learning impairment was observed in the Morris water maze

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Behavioural Brain Research

ISSN

0166-4328

e-ISSN

—

Volume of the periodical

305

Issue of the periodical within the volume

15 May

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

11

Pages from-to

247-257

UT code for WoS article

000374613400031

EID of the result in the Scopus database

2-s2.0-84960864063