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Application of a novel Active Allothetic Place Avoidance task (AAPA) in testing a pharmacological model of psychosis in rats: comparison with the Morris Water Maze

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F04%3A00102535" target="_blank" >RIV/67985823:_____/04:00102535 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Application of a novel Active Allothetic Place Avoidance task (AAPA) in testing a pharmacological model of psychosis in rats: comparison with the Morris Water Maze

  • Original language description

    Administration of a non-competitive NMDA antagonist dizocilpine (MK-801) was proposed to be an animal model of psychosis. However, the role of NMDA-receptors in organizing brain representations is not understood yet. We tested the effect of NMDA-receptorblockade by systemic administration of dizocilpine at two different doses (0.1 mg/kg or 0.2 mg/kg) in a recently designed Active Allothetic Place Avoidance, a task which requires rats to separate spatial stimuli from two continuously dissociated subsets. The effect of dizocilpine on learning in the AAPA task was compared with its effect on acquisition of the reference memory version of the Morris Water Maze task. Both doses impaired performance in the Morris Water Maze task, whereas only the higher dose impaired performance in the AAPA task. The Morris Water Maze appears to be more sensitive to dizocilpine-induced behavioral deficit than the AAPA task

  • Czech name

    Použití nové úlohy aktivního alotetického vyhýbání se místu (AAPA) v testování farmakologického modelu psychózy: srovnáni s Morrisovým vodním bludištěm

  • Czech description

    Aplikace nekompetitivních antagonistů NMDA receptoru se používá jako rozšířený model psychózy. Nicméně, role NMDA receptoru ve schopnosti organizovat prostorové informace do koherentních representací nebyla dosud testována. V této práci jsme studovali vliv aplikace 0.1 mg/kg a 0.2 mg/kg dizocilpinu na orientaci potkanů v úloze AAPA a v Morrisově vodním bludišti. V Morrisově vodním bludišti poškozovaly obě dávky účinnou orientaci, zatímco v úloze AAPA byla účinná pouze vyšší dávka. Morrisovo vodní bludiště se tedy zdá být účinnějším testem pro deficit navozený blokádou NMDA receptoru než úloha AAPA

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FH - Neurology, neuro-surgery, nuero-sciences

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GP309%2F03%2FP126" target="_blank" >GP309/03/P126: Idiothetic and allothetic navigation in rats in experimental environments: reference frames, maps and involvement of brain structures in place navigation</a><br>

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2004

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Neuroscience Letters

  • ISSN

    0304-3940

  • e-ISSN

  • Volume of the periodical

    366

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    IE - IRELAND

  • Number of pages

    5

  • Pages from-to

    162-166

  • UT code for WoS article

  • EID of the result in the Scopus database