The effect of prolonged simvastatin application on serotonin uptake, membrane microviscosity and behavioral changes in the animal model

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F16%3A43915015" target="_blank" >RIV/00023752:_____/16:43915015 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/16:00458398 RIV/00216208:11110/16:10325958 RIV/00216208:11310/16:10325958 RIV/00064165:_____/16:10325958

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S0031938416300737" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0031938416300737</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.physbeh.2016.02.029" target="_blank" >10.1016/j.physbeh.2016.02.029</a>

Result language

angličtina

Original language name

The effect of prolonged simvastatin application on serotonin uptake, membrane microviscosity and behavioral changes in the animal model

Original language description

Simvastatin and other statins (HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase inhibitors) are extensively used in clinical practices and are very effective in decreasing serum low-density lipoprotein cholesterol. However, their effect on cholesterol synthesis in central nervous system and its behavioral consequences have not been fully understood yet. We have studied selected biologic traits potentially affected by statin treatment - serotonin (5-HT) uptake in platelets, membrane microviscosity in erythrocytes, cholesterol level in the brain (amygdala; hippocampus and prefrontal cortex), as well as behavioral changes in an elevated plus maze and open field test in male Long-Evans rats, which were treated by simvastatin (30 mg/kg per day) for 2 or 4 weeks. We demonstrated: 1) a decrease in both serotonin transporter (SERT) activity and membrane microviscosity after treatment with simvastatin, 2) lower cholesterol content in all tested brain regions in animals from the simvastatin treated group, and 3) longer time spent in the open arms and a higher number of entrances to the closed arms in the elevated plus maze by animals from the simvastatin group compared to animals from the control group, but no differences in behavior in the open field test. Taken together, our results confirmed complex alterations, including behavioral changes, after the cholesterol lowering treatment. Furthermore, we discuss the possibility that the behavioral changes, traditionally interpreted as an anxiolytic effect, may be interpreted as increased impulsivity. We also confirmed that such behavioral changes may be attributed to changes in serotonergic neurotransmission.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiology &amp; Behavior

ISSN

0031-9384

e-ISSN

—

Volume of the periodical

158

Issue of the periodical within the volume

May

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

112-120

UT code for WoS article

000374607700015

EID of the result in the Scopus database

2-s2.0-84959288136