Behavioral Characterization of an Angelman Syndrome Mouse Model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F23%3A00581626" target="_blank" >RIV/68378050:_____/23:00581626 - isvavai.cz</a>
Result on the web
<a href="https://www.jove.com/t/65182/behavioral-characterization-of-an-angelman-syndrome-mouse-model" target="_blank" >https://www.jove.com/t/65182/behavioral-characterization-of-an-angelman-syndrome-mouse-model</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3791/65182" target="_blank" >10.3791/65182</a>
Alternative languages
Result language
angličtina
Original language name
Behavioral Characterization of an Angelman Syndrome Mouse Model
Original language description
This manuscript describes a battery of behavioral tests available to characterize Angelman syndrome (AS)-like phenotypes in an established murine model of AS. We use the rotarod learning paradigm, detailed gait analysis, and nest building test to detect and characterize animal motor impairments. We test animal emotionality in the open field and elevated plus maze tests, as well as the affect in the tail suspension test. When AS mice are tested in the open field test, the results should be interpreted with care, since motor dysfunctions influence mouse behavior in the maze and alter activity scores. The reproducibility and effectiveness of the presented behavioral tests has already been validated in several independent Uba3a mouse lines with different knockout variants, establishing this set of tests as an excellent validation tool in AS research. Models with the relevant construct and face validity will warrant further investigations to elucidate the pathophysiology of the disease and grant the development of causal treatments.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Jove-Journal of Visualized Experiments
ISSN
1940-087X
e-ISSN
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Volume of the periodical
2023
Issue of the periodical within the volume
200
Country of publishing house
US - UNITED STATES
Number of pages
18
Pages from-to
e65182
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-85175006976