A rat model of Alzheimer's disease based on Abeta42 and Pro-oxidative substances exhibits cognitive deficit and alterations in glutamatergic and cholinergic neurotransmitter systems
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F16%3A43915033" target="_blank" >RIV/00023752:_____/16:43915033 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/16:00459554
Result on the web
<a href="http://journal.frontiersin.org/article/10.3389/fnagi.2016.00083/full" target="_blank" >http://journal.frontiersin.org/article/10.3389/fnagi.2016.00083/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fnagi.2016.00083" target="_blank" >10.3389/fnagi.2016.00083</a>
Alternative languages
Result language
angličtina
Original language name
A rat model of Alzheimer's disease based on Abeta42 and Pro-oxidative substances exhibits cognitive deficit and alterations in glutamatergic and cholinergic neurotransmitter systems
Original language description
Alzheimer's disease (AD) is one of the most serious human, medical, and socioeconomic burdens. Here we tested the hypothesis that a rat model of AD (Samaritan; Taconic Pharmaceuticals, USA) based on the application of amyloid beta42 (Abeta42) and the pro-oxidative substances ferrous sulfate heptahydrate and L-buthionine-(S, R)-sulfoximine, will exhibit cognitive deficits and disruption of the glutamatergic and cholinergic systems in the brain. Behavioral methods included the Morris water maze (MWM; long-term memory version) and the active allothetic place avoidance (AAPA) task (acquisition and reversal), testing spatial memory and different aspects of hippocampal function. Neurochemical methods included testing of the NR1/NR2A/NR2B subunits of NMDA receptors in the frontal cortex and CHT1 transporters in the hippocampus, in both cases in the right and left hemisphere separately. Our results show that Samaritan ratsTM exhibit marked impairment in both the MWM and active place avoidance tasks, suggesting a deficit of spatial learning and memory. Moreover, Samaritan rats exhibited significant changes in NR2A expression and CHT1 activity compared to controls rats, mimicking the situation in patients with early stage AD. Taken together, our results corroborate the hypothesis that Samaritan rats are a promising model of AD in its early stages.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Aging Neuroscience
ISSN
1663-4365
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
April
Country of publishing house
CH - SWITZERLAND
Number of pages
12
Pages from-to
"Article number 83"
UT code for WoS article
000374448500001
EID of the result in the Scopus database
2-s2.0-84974533479