Subcortical volumetric abnormalities in bipolar disorder
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F16%3A43915190" target="_blank" >RIV/00023752:_____/16:43915190 - isvavai.cz</a>
Result on the web
<a href="http://www.nature.com/mp/journal/vaop/ncurrent/full/mp2015227a.html" target="_blank" >http://www.nature.com/mp/journal/vaop/ncurrent/full/mp2015227a.html</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/mp.2015.227" target="_blank" >10.1038/mp.2015.227</a>
Alternative languages
Result language
angličtina
Original language name
Subcortical volumetric abnormalities in bipolar disorder
Original language description
Considerable uncertainty exists about the defining brain changes associated with bipolar disorder (BD). Understanding and quantifying the sources of uncertainty can help generate novel clinical hypotheses about etiology and assist in the development of biomarkers for indexing disease progression and prognosis. Here we were interested in quantifying case-control differences in intracranial volume (ICV) and each of eight subcortical brain measures: nucleus accumbens, amygdala, caudate, hippocampus, globus pallidus, putamen, thalamus, lateral ventricles. In a large study of 1710 BD patients and 2594 healthy controls, we found consistent volumetric reductions in BD patients for mean hippocampus (Cohen's d=MINUS SIGN 0.232; P=3.50 x 10MINUS SIGN 7) and thalamus (d=MINUS SIGN 0.148; P=4.27 x 10MINUS SIGN 3) and enlarged lateral ventricles (d=MINUS SIGN 0.260; P=3.93 x 10MINUS SIGN 5) in patients. No significant effect of age at illness onset was detected. Stratifying patients based on clinical subtype (BD type I or type II) revealed that BDI patients had significantly larger lateral ventricles and smaller hippocampus and amygdala than controls. However, when comparing BDI and BDII patients directly, we did not detect any significant differences in brain volume. This likely represents similar etiology between BD subtype classifications. Exploratory analyses revealed significantly larger thalamic volumes in patients taking lithium compared with patients not taking lithium. We detected no significant differences between BDII patients and controls in the largest such comparison to date. Findings in this study should be interpreted with caution and with careful consideration of the limitations inherent to meta-analyzed neuroimaging comparisons.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
AN - Psychology
OECD FORD branch
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Result continuities
Project
—
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular Psychiatry
ISSN
1359-4184
e-ISSN
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Volume of the periodical
21
Issue of the periodical within the volume
12
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
1710-1716
UT code for WoS article
000388720600010
EID of the result in the Scopus database
2-s2.0-84995699210