The association between familial risk and brain abnormalities is disease specific: an ENIGMA-Relatives study of schizophrenia and Bipolar disorder

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F19%3A43919959" target="_blank" >RIV/00023752:_____/19:43919959 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/19:43918607

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0006322319314374?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0006322319314374?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biopsych.2019.03.985" target="_blank" >10.1016/j.biopsych.2019.03.985</a>

Result language

angličtina

Original language name

The association between familial risk and brain abnormalities is disease specific: an ENIGMA-Relatives study of schizophrenia and Bipolar disorder

Original language description

BACKGROUND: Schizophrenia and bipolar disorder share genetic liability, and some structural brain abnormalities are common to both conditions. First-degree relatives of patients with schizophrenia (FDRs-SZ) show similar brain abnormalities to patients, albeit with smaller effect sizes. Imaging findings in first-degree relatives of patients with bipolar disorder (FDRs-BD) have been inconsistent in the past, but recent studies report regionally greater volumes compared with control subjects. METHODS: We performed a meta-analysis of global and subcortical brain measures of 6008 individuals (1228 FDRs-SZ, 852 FDRs-BD, 2246 control subjects, 1016 patients with schizophrenia, 666 patients with bipolar disorder) from 34 schizophrenia and/or bipolar disorder family cohorts with standardized methods. Analyses were repeated with a correction for intracranial volume (ICV) and for the presence of any psychopathology in the relatives and control subjects. RESULTS: FDRs-BD had significantly larger ICV (d = +0.16, q &lt; .05 corrected), whereas FDRs-SZ showed smaller thalamic volumes than control subjects (d = -0.12, q &lt; .05 corrected). ICV explained the enlargements in the brain measures in FDRs-BD. In FDRs-SZ, after correction for ICV, total brain, cortical gray matter, cerebral white matter, cerebellar gray and white matter, and thalamus volumes were significantly smaller; the cortex was thinner (d &lt; -0.09, q &lt; .05 corrected); and third ventricle was larger (d = +0.15, q &lt; .05 corrected). The findings were not explained by psychopathology in the relatives or control subjects. CONCLUSIONS: Despite shared genetic liability, FDRs-SZ and FDRs-BD show a differential pattern of structural brain abnormalities, specifically a divergent effect in ICV. This may imply that the neurodevelopmental trajectories leading to brain anomalies in schizophrenia or bipolar disorder are distinct.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30215 - Psychiatry

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biological Psychiatry

ISSN

0006-3223

e-ISSN

—

Volume of the periodical

86

Issue of the periodical within the volume

7

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

545-556

UT code for WoS article

000485217300010

EID of the result in the Scopus database

2-s2.0-85071651930