Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F22%3A43920642" target="_blank" >RIV/00216208:11120/22:43920642 - isvavai.cz</a>

Alternative codes found

RIV/00023752:_____/21:43920420

Result on the web

<a href="https://doi.org/10.1002/hbm.25206" target="_blank" >https://doi.org/10.1002/hbm.25206</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/hbm.25206" target="_blank" >10.1002/hbm.25206</a>

Result language

angličtina

Original language name

Intelligence, educational attainment, and brain structure in those at familial high-risk for schizophrenia or bipolar disorder

Original language description

First-degree relatives of patients diagnosed with schizophrenia (SZ-FDRs) show similar patterns of brain abnormalities and cognitive alterations to patients, albeit with smaller effect sizes. First-degree relatives of patients diagnosed with bipolar disorder (BD-FDRs) show divergent patterns; on average, intracranial volume is larger compared to controls, and findings on cognitive alterations in BD-FDRs are inconsistent. Here, we performed a meta-analysis of global and regional brain measures (cortical and subcortical), current IQ, and educational attainment in 5,795 individuals (1,103 SZ-FDRs, 867 BD-FDRs, 2,190 controls, 942 schizophrenia patients, 693 bipolar patients) from 36 schizophrenia and/or bipolar disorder family cohorts, with standardized methods. Compared to controls, SZ-FDRs showed a pattern of widespread thinner cortex, while BD-FDRs had widespread larger cortical surface area. IQ was lower in SZ-FDRs (d = -0.42, p = 3 x 10(-5) ), with weak evidence of IQ reductions among BD-FDRs (d = -0.23, p = .045). Both relative groups had similar educational attainment compared to controls. When adjusting for IQ or educational attainment, the group-effects on brain measures changed, albeit modestly. Changes were in the expected direction, with less pronounced brain abnormalities in SZ-FDRs and more pronounced effects in BD-FDRs. To conclude, SZ-FDRs and BD-FDRs show a differential pattern of structural brain abnormalities. In contrast, both had lower IQ scores and similar school achievements compared to controls. Given that brain differences between SZ-FDRs and BD-FDRs remain after adjusting for IQ or educational attainment, we suggest that differential brain developmental processes underlying predisposition for schizophrenia or bipolar disorder are likely independent of general cognitive impairment.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30215 - Psychiatry

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Human Brain Mapping

ISSN

1065-9471

e-ISSN

1097-0193

Volume of the periodical

43

Issue of the periodical within the volume

1, Special Issue

Country of publishing house

US - UNITED STATES

Number of pages

17

Pages from-to

414-430

UT code for WoS article

000575642800001

EID of the result in the Scopus database

2-s2.0-85092137687