New structural brain imaging endophenotype in bipolar disorder

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A43898663" target="_blank" >RIV/00216208:11120/12:43898663 - isvavai.cz</a>
Alternative codes found
RIV/00023752:_____/12:43913788
Result on the web
<a href="http://dx.doi.org/10.1038/mp.2011.3" target="_blank" >http://dx.doi.org/10.1038/mp.2011.3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/mp.2011.3" target="_blank" >10.1038/mp.2011.3</a>

Result language
angličtina
Original language name
New structural brain imaging endophenotype in bipolar disorder
Original language description
Neuroimaging studies suggest anterior-limbic structural brain abnormalities in patients with bipolar disorder (BD), but few studies have shown these abnormalities in unaffected but genetically liable family members. In this study, we report morphometriccorrelates of genetic risk for BD using voxel-based morphometry. In 35 BD type I (BD-I) patients, 20 unaffected firstdegree relatives (UAR) of BD patients and 40 healthy control subjects underwent 3 T magnetic resonance scanner imaging. Preprocessing ofimages used DARTEL (diffeomorphic anatomical registration through exponentiated lie algebra) for voxel-based morphometry in SPM8 (Wellcome Department of Imaging Neuroscience, London, UK). The whole-brain analysis revealed that the gray matter (GM) volumes of the left anterior insula and right inferior fronta gyrus showed a significant main effect of diagnosis. Multiple comparison analysis showed that the BD-I patients and the UAR subjects had smaller left anterior insular GM volumes comp
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FL - Psychiatry, sexology
OECD FORD branch
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Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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