Insulin resistance, diabetes mellitus, and brain dtructure in bipolar disorders

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F14%3A43909414" target="_blank" >RIV/00216208:11120/14:43909414 - isvavai.cz</a>

Alternative codes found

RIV/00023752:_____/14:43914666

Result on the web

<a href="http://dx.doi.org/10.1038/npp.2014.148" target="_blank" >http://dx.doi.org/10.1038/npp.2014.148</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/npp.2014.148" target="_blank" >10.1038/npp.2014.148</a>

Result language

angličtina

Original language name

Insulin resistance, diabetes mellitus, and brain dtructure in bipolar disorders

Original language description

Type 2 diabetes mellitus (T2DM) damages the brain, especially the hippocampus, and frequently co-occurs with bipolar disorders (BD). Reduced hippocampal volumes are found only in some studies of BD subjects and may thus be secondary to the presence of certain clinical variables. Studying BD patients with abnormal glucose metabolism could help identify preventable risk factors for hippocampal atrophy in BD. We compared brain structure using optimized voxel-based morphometry of 1.5T MRI scans in 33 BD subjects with impaired glucose metabolism (19 with insulin resistance/glucose intolerance (IR/GI), 14 with T2DM), 15 euglycemic BD participants and 11 euglycemic, nonpsychiatric controls. The group of BD patients with IR, GI or T2DM had significantly smaller hippocampal volumes than the euglycemic BD participants (corrected p=0.02) or euglycemic, nonpsychiatric controls (corrected p=0.004). Already the BD subjects with IR/GI had smaller hippocampal volumes than euglycemic BD participants (t

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuropsychopharmacology

ISSN

0893-133X

e-ISSN

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Volume of the periodical

39

Issue of the periodical within the volume

12

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

2910-2918

UT code for WoS article

000343682500021

EID of the result in the Scopus database

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