Type 2 diabetes mellitus: a potentially modifiable risk factor for neurochemical brain changes in bipolar disorders

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F15%3A43909408" target="_blank" >RIV/00216208:11120/15:43909408 - isvavai.cz</a>

Alternative codes found

RIV/00023752:_____/15:43914530

Result on the web

<a href="http://dx.doi.org/10.1016/j.biopsych.2013.11.007" target="_blank" >http://dx.doi.org/10.1016/j.biopsych.2013.11.007</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biopsych.2013.11.007" target="_blank" >10.1016/j.biopsych.2013.11.007</a>

Result language

angličtina

Original language name

Type 2 diabetes mellitus: a potentially modifiable risk factor for neurochemical brain changes in bipolar disorders

Original language description

Background: Neuroimaging changes in bipolar disorder (BD) may be secondary to the presence of certain clinical factors. Type 2 diabetes mellitus (T2DM) damages the brain and frequently co-occurs with BD. Studying patients with both T2DM and BD could helpidentify preventable risk factors for neuroimaging changes in BD. Methods: We used 1.5T magnetic resonance spectroscopy to measure prefrontal N-acetylaspartate (NAA), which is mainly localized in neurons, and total creatine (tCr), an energy metabolite,in 19 BD patients with insulin resistance/glucose intolerance (BD + IR/GI), 14 BD subjects with T2DM (BD + T2DM), 15 euglycemic BD participants, and 11 euglycemic, nonpsychiatric control. Results: The levels of NAA and tCr were lowest among BD + T2DM, intermediate in the BD + IR/GI, and highest among the euglycemic BD and control subjects (F3,55 = 4.57, p = .006; F3,55 = 2.92, p = .04, respectively). Even the BD + IR/GI subjects had lower NAA than the euglycemic participants (t43 = 2.13,

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biological Psychiatry

ISSN

0006-3223

e-ISSN

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Volume of the periodical

77

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

295-303

UT code for WoS article

000346845500018

EID of the result in the Scopus database

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