Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F16%3A43915209" target="_blank" >RIV/00023752:_____/16:43915209 - isvavai.cz</a>
Result on the web
<a href="http://hmg.oxfordjournals.org/content/early/2016/09/08/hmg.ddw181.long" target="_blank" >http://hmg.oxfordjournals.org/content/early/2016/09/08/hmg.ddw181.long</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/hmg/ddw181" target="_blank" >10.1093/hmg/ddw181</a>
Alternative languages
Result language
angličtina
Original language name
Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder
Original language description
Bipolar disorder (BD) is a genetically complex mental illness characterized by severe oscillations of mood and behaviour. Genome-wide association studies (GWAS) have identified several risk loci that together account for a small portion of the heritability. To identify additional risk loci, we performed a two-stage meta-analysis of >9 million genetic variants in 9,784 bipolar disorder patients and 30,471 controls, the largest GWAS of BD to date. In this study, to increase power we used TILDE OPERATOR+D912,000 lithium-treated cases with a long-term diagnosis of BD from the Consortium on Lithium Genetics, excess controls, and analytic methods optimized for markers on the X-chromosome. In addition to four known loci, results revealed genome-wide significant associations at two novel loci: an intergenic region on 9p21.3 (rs12553324, P = 5.87 x 10 - 9; odds ratio (OR) = 1.12) and markers within ERBB2 (rs2517959, P = 4.53 x 10 - 9; OR = 1.13). No significant X-chromosome associations were detected and X-linked markers explained very little BD heritability. The results add to a growing list of common autosomal variants involved in BD and illustrate the power of comparing well-characterized cases to an excess of controls in GWAS.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FL - Psychiatry, sexology
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Human Molecular Genetics
ISSN
0964-6906
e-ISSN
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Volume of the periodical
25
Issue of the periodical within the volume
15
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
3383-3394
UT code for WoS article
000393077300018
EID of the result in the Scopus database
2-s2.0-85014343531