Genome-wide association study identifies 30 loci associated with bipolar disorder
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F19%3A43920204" target="_blank" >RIV/00023752:_____/19:43920204 - isvavai.cz</a>
Result on the web
<a href="https://www.nature.com/articles/s41588-019-0397-8" target="_blank" >https://www.nature.com/articles/s41588-019-0397-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41588-019-0397-8" target="_blank" >10.1038/s41588-019-0397-8</a>
Alternative languages
Result language
angličtina
Original language name
Genome-wide association study identifies 30 loci associated with bipolar disorder
Original language description
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide association study (GWAS) including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants with P < 1 x 10(-4) in an additional 9,412 cases and 137,760 controls. Eight of the 19 variants that were genome-wide significant (P < 5 x 10(-8)) in the discovery GWAS were not genome-wide significant in the combined analysis, consistent with small effect sizes and limited power but also with genetic heterogeneity. In the combined analysis, 30 loci were genome-wide significant, including 20 newly identified loci. The significant loci contain genes encoding ion channels, neurotransmitter transporters and synaptic components. Pathway analysis revealed nine significantly enriched gene sets, including regulation of insulin secretion and endocannabinoid signaling. Bipolar I disorder is strongly genetically correlated with schizophrenia, driven by psychosis, whereas bipolar II disorder is more strongly correlated with major depressive disorder. These findings address key clinical questions and provide potential biological mechanisms for bipolar disorder.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30215 - Psychiatry
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature Genet
ISSN
1061-4036
e-ISSN
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Volume of the periodical
51
Issue of the periodical within the volume
5
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
793-803
UT code for WoS article
000466842000007
EID of the result in the Scopus database
2-s2.0-85065180508