Identification of novel loci and new risk variant in known loci for colorectal cancer risk in East Asians

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F20%3A10402460" target="_blank" >RIV/00216208:11110/20:10402460 - isvavai.cz</a>

Alternative codes found

RIV/68378041:_____/20:00539190 RIV/00216208:11140/20:10402460

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Es_.3cB6sC" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Es_.3cB6sC</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1158/1055-9965.EPI-19-0755" target="_blank" >10.1158/1055-9965.EPI-19-0755</a>

Result language

angličtina

Original language name

Identification of novel loci and new risk variant in known loci for colorectal cancer risk in East Asians

Original language description

BACKGROUND: Risk variants identified so far for colorectal cancer (CRC) explain only a small proportion of familial risk of this cancer, particularly in Asians. METHODS: We performed a genome-wide association study (GWAS) of CRC in East Asians including 23,572 CRC cases and 48,700 controls. To identify novel risk loci, we selected sixty promising risk variants for replication using data from 58,131 CRC cases and 67,347 controls of European descent. To identify additional risk variants in known CRC loci, we performed conditional analyses in East Asians. RESULTS: An indel variant, rs67052019 at 1p13.3, was found to be associated with CRC risk at P=3.9 x 10-8 in Asians (OR per allele deletion=1.13, 95%CI=1.08-1.18). This association was replicated in European descendants using a variant (rs2938616) in complete linkage disequilibrium with rs67052019 (P=7.7 x 10-3). Of the remaining 59 variants, 12 showed an association at P&lt;0.05 in the European-ancestry study, including rs11108175 and rs9634162 at P&lt;5x10-8 and two variants with an association near the genome-wide significance level (rs60911071, P=5.8x10-8; rs62558833, P=7.5x10-8) in the combined analyses of Asian- and European-ancestry data. In addition, using data from East Asians, we identified 13 new risk variants at 11 loci reported from previous GWAS. CONCLUSIONS: In this large GWAS, we identified three novel risk loci and two highly suggestive loci for CRC risk and provided evidence for potential roles of multiple genes and pathways in the etiology of CRC. IMPACT: Our study provides novel data to improve the understanding of the genetic basis for CRC risk.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10600 - Biological sciences

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancer Epidemiology, Biomarkers &amp; Prevention

ISSN

1055-9965

e-ISSN

—

Volume of the periodical

29

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

477-486

UT code for WoS article

000521285500025

EID of the result in the Scopus database

2-s2.0-85079075708