Genome-wide association study identifies multiple risk loci for renal cell carcinoma

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10360567" target="_blank" >RIV/00216208:11110/17:10360567 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/17:10360567 RIV/00209805:_____/17:00077938 RIV/61989592:15110/17:73581798
Result on the web
<a href="http://dx.doi.org/10.1038/ncomms15724" target="_blank" >http://dx.doi.org/10.1038/ncomms15724</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/ncomms15724" target="_blank" >10.1038/ncomms15724</a>

Result language
angličtina
Original language name
Genome-wide association study identifies multiple risk loci for renal cell carcinoma
Original language description
Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P = 3.1 x 10(-10)), 3p22.1 (rs67311347, P = 2.5 x 10(-8)), 3q26.2 (rs10936602, P = 8.8 x 10(-9)), 8p21.3 (rs2241261, P = 5.8 x 10(-9)), 10q24.33-q25.1 (rs11813268, P = 3.9 x 10(-8)), 11q22.3 (rs74911261, P = 2.1 x 10(-10)) and 14q24.2 (rs4903064, P = 2.2 x 10(-24)). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30304 - Public and environmental health

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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