Genome-wide association study identifies multiple risk loci for renal cell carcinoma.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F17%3A73581798" target="_blank" >RIV/61989592:15110/17:73581798 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/17:10360567 RIV/00216208:11130/17:10360567 RIV/00209805:_____/17:00077938
Result on the web
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472706/" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472706/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/ncomms15724" target="_blank" >10.1038/ncomms15724</a>
Alternative languages
Result language
angličtina
Original language name
Genome-wide association study identifies multiple risk loci for renal cell carcinoma.
Original language description
Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P=3.1 × 10-10), 3p22.1 (rs67311347, P=2.5 × 10-8), 3q26.2 (rs10936602, P=8.8 × 10-9), 8p21.3 (rs2241261, P=5.8 × 10-9), 10q24.33-q25.1 (rs11813268, P=3.9 × 10-8), 11q22.3 (rs74911261, P=2.1 × 10-10) and 14q24.2 (rs4903064, P=2.2 × 10-24). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30302 - Epidemiology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature Communications
ISSN
2041-1723
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
8
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
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UT code for WoS article
000402963900001
EID of the result in the Scopus database
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