Tractography of fornix and gyrus subcallosus and paraterminalis in patients with Alzheimer's disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F16%3A43915380" target="_blank" >RIV/00023752:_____/16:43915380 - isvavai.cz</a>

Result on the web

<a href="http://www.konferencestarnuti.cz/files/Starnuti_2016_sbornik.pdf" target="_blank" >http://www.konferencestarnuti.cz/files/Starnuti_2016_sbornik.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Tractography of fornix and gyrus subcallosus and paraterminalis in patients with Alzheimer's disease

Original language description

Alzheimer's disease (AD) is neurodegenerative disease characterized by extracellular, insoluble beta-amyloid plaques and intracytoplasmic tau-associated neurofibrillary tangles. This process leads to the loss of neurons and connectivity. The aim of this study was to measure parameters of fornix and gyrus subcallosus and paraterminalis in patients with AD (34) and healthy controls (34) of similar age. Probands were divided by a neurologist based on psychological and clinical examination. Difusion tensor imaging scans were acquired on 3T MRI. The area of fornix and gyrus subcallosus and paraterminalis was drawn manually according to anatomical position in all dimensions on T2 weighted MRI images. Then tractography, visualization of neural tracts, was created. We obtained these parameters: number of tracts, tract length, tract volume, quantitative anisotropy (QA) and generalized fractional anisotropy (GFA). There was statistically significant decrease of number of tracts and tract length and statistically significant increase of QA in the area of left fornix in patients with AD. Statistically significant decrease of number of tracts, tract length and GFA was also observed in the area of right fornix in patients with AD. There was an increase of number of tracts, tract volume, QA and GFA in the left and right area of gyrus subcallosus and paraterminalis in patients with AD. Fornix is a part of the limbic system associated with episodic memory, the ability to recall an event from recent or distant past. Degeneration of fornix according to DTI analysis explains long-term memory loss in patients with AD. There was significant increase in parameters in the area of gyrus subcallosus and paraterminalis, area associated with short-term memory. A higher GFA value, registered in gyrus subcallosus and paraterminalis, indicates better integrity of the neural fiber bundles which might represent the compensation of AD. Tractography could help diagnose AD.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

AN - Psychology

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Stárnutí 2016: Sborník příspěvků z 3. Gerontologické mezioborové konference

ISBN

978-80-87878-22-4

ISSN

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e-ISSN

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Number of pages

5

Pages from-to

94-98

Publisher name

Univerzita Karlova. 3. lékařská fakulta

Place of publication

Praha

Event location

Praha

Event date

Oct 21, 2016

Type of event by nationality

CST - Celostátní akce

UT code for WoS article

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