Endocannabinoid system in sexual motivational processes: is it a novel therapeutic horizon?

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F17%3A43915269" target="_blank" >RIV/00023752:_____/17:43915269 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/17:00097677 RIV/00216208:11120/17:43912621
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S1043661816312385" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1043661816312385</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.phrs.2016.11.021" target="_blank" >10.1016/j.phrs.2016.11.021</a>

Result language
angličtina
Original language name
Endocannabinoid system in sexual motivational processes: is it a novel therapeutic horizon?
Original language description
The endocannabinoid system (ECS), which is composed of the cannabinoid receptors types 1 and 2 (CB1 and CB2) for marijuana’s psychoactive ingredient delta9-tetrahydrocannabinol (delta9-THC), the endogenous ligands (AEA and 2-AG) and the enzymatic systems involved in their biosynthesis and degradation, recently emerged as important modulator of emotional and non-emotional behaviors. For centuries, in addition to its recreational actions, several contradictory claims regarding the effects of Cannabis use in sexual functioning and behavior (e.g. aphrodisiac vs anti-aphrodisiac) of both sexes have been accumulated. The identification of delta9-THC and later on, the discovery of the ECS have opened a potential therapeutic target for sexual dysfunctions, given the partial efficacy of current pharmacological treatment. In agreement with the bidirectional modulation induced by cannabinoids on several behavioral responses, the endogenous cannabinoid AEA elicited biphasic effects on sexual behavior as well. The present article reviews current available knowledge on herbal, synthetic and endogenous cannabinoids with respect to the modulation of several aspects of sexuality in preclinical and human studies, highlighting their therapeutic potential.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30215 - Psychiatry

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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