Transient inactivation of the anterior cingulate cortex in rats disrupts avoidance of a dynamic object

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F17%3A43915347" target="_blank" >RIV/00023752:_____/17:43915347 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/17:00485342

Result on the web

<a href="http://www.sciencedirect.com/science/article/pii/S1074742717300023#s0005" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1074742717300023#s0005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.nlm.2017.01.003" target="_blank" >10.1016/j.nlm.2017.01.003</a>

Result language

angličtina

Original language name

Transient inactivation of the anterior cingulate cortex in rats disrupts avoidance of a dynamic object

Original language description

Although animals often learn and monitor the spatial properties of relevant moving objects such as conspecifics and predators to properly organize their own spatial behavior, the underlying brain substrate has received little attention and hence remains elusive. Because the anterior cingulate cortex (ACC) participates in conflict monitoring and effort-based decision making, and ACC neurons respond to objects in the environment, it may also play a role in the monitoring of moving cues and exerting the appropriate spatial response. We used a robot avoidance task in which a rat had to maintain at least a 25cm distance from a small programmable robot to avoid a foot shock. In successive sessions, we trained ten Long Evans male rats to avoid a fast-moving robot (4 cm/s), a stationary robot, and a slow-moving robot (1 cm/s). In each condition, the ACC was transiently inactivated by bilateral injections of muscimol in the penultimate session and a control saline injection was given in the last session. Compared to the corresponding saline session, ACC-inactivated rats received more shocks when tested in the fast-moving condition, but not in the stationary or slow robot conditions. Furthermore, ACC-inactivated rats less frequently responded to an approaching robot with appropriate escape responses although their response to shock stimuli remained preserved. Since we observed no effect on slow or stationary robot avoidance, we conclude that the ACC may exert cognitive efforts for monitoring dynamic updating of the position of an object, a role complementary to the dorsal hippocampus.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neurobiology of Learning and Memory

ISSN

1074-7427

e-ISSN

—

Volume of the periodical

139

Issue of the periodical within the volume

March

Country of publishing house

GB - UNITED KINGDOM

Number of pages

5

Pages from-to

144-148

UT code for WoS article

000396386200017

EID of the result in the Scopus database

2-s2.0-85010390673