Functional inactivation of the rat hippocampus disrupts avoidance of a moving object
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F11%3A10110144" target="_blank" >RIV/00216208:11310/11:10110144 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/11:00364564
Result on the web
<a href="http://dx.doi.org/10.1073/pnas.1102525108" target="_blank" >http://dx.doi.org/10.1073/pnas.1102525108</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1073/pnas.1102525108" target="_blank" >10.1073/pnas.1102525108</a>
Alternative languages
Result language
angličtina
Original language name
Functional inactivation of the rat hippocampus disrupts avoidance of a moving object
Original language description
The hippocampus is well known for its critical involvement in spatial memory and information processing. In this study, we examined the effect of bilateral hippocampal inactivation with tetrodotoxin (TTX) in an "enemy avoidance" task. In this paradigm, arat foraging on a circular platform (82 cm diameter) is trained to avoid a moving robot in 20-min sessions. Whenever the rat is located within 25 cm of the robot's center, it receives a mild electrical foot shock, which may be repeated until the subjectmakes an escape response to a safe distance. Seventeen young male Long-Evans rats were implanted with cannulae aimed at the dorsal hippocampus 14 d before the start of the training. After 6 d of training, each rat received a bilateral intrahippocampal infusion of TTX (5 ng in 1 mu L) 40 min before the training session on day 7. The inactivation severely impaired avoidance of a moving robot (n = 8). No deficit was observed in a different group of rats (n = 9) that avoided a stable robot
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Proceedings of the National Academy of Sciences of the United States of America
ISSN
0027-8424
e-ISSN
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Volume of the periodical
108
Issue of the periodical within the volume
13
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
5414-5418
UT code for WoS article
000288894800054
EID of the result in the Scopus database
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