Individual prolactin reactivity modulates response of nucleus accumbens to erotic stimuli during acute cannabis intoxication: an fMRI pilot study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F17%3A43915390" target="_blank" >RIV/00023752:_____/17:43915390 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/17:10362740 RIV/00216208:11120/17:43915101 RIV/60461373:22330/17:43913322 RIV/00023001:_____/17:00075974
Result on the web
<a href="https://link.springer.com/article/10.1007%2Fs00213-017-4601-1" target="_blank" >https://link.springer.com/article/10.1007%2Fs00213-017-4601-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00213-017-4601-1" target="_blank" >10.1007/s00213-017-4601-1</a>
Alternative languages
Result language
angličtina
Original language name
Individual prolactin reactivity modulates response of nucleus accumbens to erotic stimuli during acute cannabis intoxication: an fMRI pilot study
Original language description
Rationale: Self-report studies indicate that cannabis could increase sexual desire in some users. We hypothesized that intoxication increases activation of brain areas responsive to visual erotica, which could be useful in the treatment of hypoactive sexual desire disorder, a condition marked by a lack of sexual desire. Objectives: To assess the aphrodisiacal properties of cannabis. Methods: We conducted an open-randomized study with 21 heterosexual casual cannabis users. A 3T MRI was used to measure brain activation in response to erotic pictures. Blood samples were collected to determine the serum levels of cannabinoids, cortisol and prolactin. Participants were grouped according to whether they had ever experienced any aphrodisiacal effects during intoxication (Group A) or not (Group non- A). Results: Intoxication was found to significantly increase activation in the right nucleus accumbens in the Group A while significantly decreasing activation in the Group non-A. There was also a significant interaction between the group and intoxication, with elevated prolactin in the Group non-A during intoxication. No intoxication-related differences in subjective picture evaluations were found. Conclusion: Cannabis intoxication increases activation of the right nucleus accumbens to erotic stimuli. This effect is limited to users whose prolactin is not elevated in response to intoxication. This effect may be useful in the treatment of low sexual desire.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Psychopharmacology
ISSN
0033-3158
e-ISSN
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Volume of the periodical
234
Issue of the periodical within the volume
13
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
1933-1943
UT code for WoS article
000403476500001
EID of the result in the Scopus database
2-s2.0-85017435327