Cannabis-induced altered states of consciousness are associated with specific dynamic brain connectivity states

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F19%3A00506880" target="_blank" >RIV/67985807:_____/19:00506880 - isvavai.cz</a>

Alternative codes found

RIV/00023752:_____/19:43919990 RIV/00216208:11110/19:10395318 RIV/00216208:11120/19:43918420

Result on the web

<a href="http://dx.doi.org/10.1177/0269881119849814" target="_blank" >http://dx.doi.org/10.1177/0269881119849814</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1177/0269881119849814" target="_blank" >10.1177/0269881119849814</a>

Result language

angličtina

Original language name

Cannabis-induced altered states of consciousness are associated with specific dynamic brain connectivity states

Original language description

Background: Cannabis, and specifically one of its active compounds delta-9-tetrahydrocannabinol in recreational doses, has a variety of effects on cognitive processes. Most studies employ resting state functional magnetic resonance imaging techniques to assess the stationary effects of cannabis and to-date one report addressed the impact of delta-9-tetrahydrocannabinol on the dynamics of whole-brain functional connectivity. Methods: Using a repeated-measures, within-subjects design, 19 healthy occasional cannabis users (smoking cannabis <= 2 per week) underwent resting state functional magnetic resonance imaging scans. Each subject underwent two scans: in the intoxicated condition, shortly after smoking a cannabis cigarette, and in the non-intoxicated condition, with the subject being free from cannabinoids for at least one week before. All sessions were randomized and performed in a four-week interval. Data were analysed employing a standard independent component analysis approach with subsequent tracking of the functional connectivity dynamics, which allowed six connectivity clusters (states) to be individuated. Results: Using standard independent component analysis in resting state functional connectivity, a group effect was found in the precuneus connectivity. With a dynamic independent component analysis approach, we identified one transient connectivity state, characterized by high connectivity within and between auditory and somato-motor cortices and anti-correlation with subcortical structures and the cerebellum that was only found during the intoxicated condition. Behavioural measures of the subjective experiences of changed perceptions and tetrahydrocannabinol plasma levels during intoxication were associated with this state. Conclusions: With the help of the dynamic connectivity approach we could elucidate neural correlates of the transitory perceptual changes induced by delta-9-tetrahydrocannabinol in cannabis users, and possibly identify a biomarker of cannabis intoxication.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Psychopharmacology

ISSN

0269-8811

e-ISSN

—

Volume of the periodical

33

Issue of the periodical within the volume

7

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

811-821

UT code for WoS article

000472769400006

EID of the result in the Scopus database

2-s2.0-85067854318