Theory of Mind Skills Are Related to Resting-State Frontolimbic Connectivity in Schizophrenia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F18%3A00069169" target="_blank" >RIV/00159816:_____/18:00069169 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/18:00105775 RIV/65269705:_____/18:00069169
Result on the web
<a href="http://dx.doi.org/10.1089/brain.2017.0563" target="_blank" >http://dx.doi.org/10.1089/brain.2017.0563</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1089/brain.2017.0563" target="_blank" >10.1089/brain.2017.0563</a>
Alternative languages
Result language
angličtina
Original language name
Theory of Mind Skills Are Related to Resting-State Frontolimbic Connectivity in Schizophrenia
Original language description
Patients with schizophrenia (SCH) often demonstrate impairment in social-cognitive functions as well as disturbances in large-scale network connectivity. The ventromedial prefrontal cortex (vmPFC) is a core region of the default mode network, with projections to limbic structures. It plays an important role in social and emotional decision-making. We investigated whether resting-state functional connectivity (FC) relates to the cognitive and affective domains of theory of mind (ToM). Twenty-three SCH patients and 19 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging scanning. vmPFC seed connectivity was correlated with behavioral measures assessing ToM domains. SCH performed less well than HCs in both ToM task domains. An analysis of the resting-state FC revealed that SCH had reduced connectivity from the vmPFC to the subcallosal cortex, right amygdala, and right hippocampus as a function of behavioral scores in both ToM domains. Within-group analyses indicated that in HCs, the performance in ToM was positively associated with frontoamygdalar resting-state connectivity, whereas in SCH, the performance in ToM was negatively associated with the frontosubcallosal connectivity. Differences in the pattern of the resting-state frontolimbic connectivity and its associations with performance in ToM tasks between the two study groups might represent a different setup for processing social information in patients with SCH.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Brain Connectivity
ISSN
2158-0014
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
350-361
UT code for WoS article
000452155400005
EID of the result in the Scopus database
2-s2.0-85052093623