Trans-generational neurochemical modulation of methamphetamine in the adult brain of the Wistar rat
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F17%3A43915464" target="_blank" >RIV/00023752:_____/17:43915464 - isvavai.cz</a>
Alternative codes found
RIV/67985807:_____/17:00474857 RIV/00216208:11120/17:43913230 RIV/60461373:22310/17:43915067
Result on the web
<a href="https://link.springer.com/article/10.1007%2Fs00204-017-1969-y" target="_blank" >https://link.springer.com/article/10.1007%2Fs00204-017-1969-y</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00204-017-1969-y" target="_blank" >10.1007/s00204-017-1969-y</a>
Alternative languages
Result language
angličtina
Original language name
Trans-generational neurochemical modulation of methamphetamine in the adult brain of the Wistar rat
Original language description
Chronic methamphetamine (METH) abuse has been shown to elicit strong neurotoxic effects. Yet, with an increasing number of children born to METH abusing mothers maturing into adulthood, one important question is how far do the neurotoxic effects of METH alter various neurotransmitter systems in the adult METH-exposed offspring. The purpose of this study was to investigate long-term trans-generational neurochemical changes, following prenatal METH exposure, in the adult Wistar rat brain. METH or saline (SAL-control animals) was administered to pregnant dams throughout the entire gestation period (G0-G22). At postnatal day 90, dopamine, serotonin, glutamate and GABA were measured in the adult brain before (baseline) and after a METH re-administration using in vivo microdialysis and liquid chromatography/mass spectrometry. The results show that METH-exposure increased basal levels of monoamines and glutamate, but decreased GABA levels in all measured brain regions. Acute challenge with METH injection in the METH-exposed group induced a lower increase in the monoamine system relative to the increase in the GABAergic and glutamatergic system. The data show that prenatal METH exposure has strong effects on the monoaminergic, GABAergic and glutamatergic system even when exposure to METH was limited to the prenatal phase. Toxicological effects of METH have therefore longer lasting effects as currently considered and seem to affect the excitatory-inhibitory balance in the brain having strong implications for cognitive and behavioral functioning.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30108 - Toxicology
Result continuities
Project
<a href="/en/project/LO1611" target="_blank" >LO1611: Sustainability for The National Institute of Mental Health</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Archives of Toxicology
ISSN
0340-5761
e-ISSN
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Volume of the periodical
91
Issue of the periodical within the volume
10
Country of publishing house
DE - GERMANY
Number of pages
12
Pages from-to
3373-3384
UT code for WoS article
000411386000015
EID of the result in the Scopus database
2-s2.0-85018761685