Subclinical cardiac dysfunction and brain health in midlife: CARDIA (coronary artery risk development in young adults) brain magnetic resonance imaging substudy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F17%3A43919038" target="_blank" >RIV/00023752:_____/17:43919038 - isvavai.cz</a>
Result on the web
<a href="http://jaha.ahajournals.org/content/6/12/e006750" target="_blank" >http://jaha.ahajournals.org/content/6/12/e006750</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1161/JAHA.117.006750" target="_blank" >10.1161/JAHA.117.006750</a>

Result language
angličtina
Original language name
Subclinical cardiac dysfunction and brain health in midlife: CARDIA (coronary artery risk development in young adults) brain magnetic resonance imaging substudy
Original language description
Background: We investigated whether cardiac parameters in young adulthood are associated with indicators of brain health in mid-life. Methods and Results: This study includes 648 participants from The Coronary Artery Risk Development in Young Adults Study (52% women, 38% African Americans). We studied associations of cardiac parameters assessed by echocardiography (left ventricular ejection fraction, left atrial volume and left ventricular mass) in young adulthood (mean age 30 years) with brain measures obtained by MRI (total brain, gray and white matter volume, white matter integrity, abnormal white matter) in mid-life (mean age 50 years). In 406 individuals with complete measurements, higher left atrial volume was associated with lower white matter fractional anisotropy, independently of traditional cardiovascular risk factors (β=-0.002; p=0.016). The association was strongest in African Americans and in men. Conclusions: Higher left atrial volume in early adulthood is associated with impairment of white matter integrity in mid-life. Interventions to improve cardiac function in young adults may benefit brain health and should be targeted in particular at African American men.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30302 - Epidemiology

Project
<a href="/en/project/LO1611" target="_blank" >LO1611: Sustainability for The National Institute of Mental Health</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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