Clinical perspectives of lithium's neuroprotective effect

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F18%3A43919253" target="_blank" >RIV/00023752:_____/18:43919253 - isvavai.cz</a>

Result on the web

<a href="https://www.ncbi.nlm.nih.gov/pubmed/29270949" target="_blank" >https://www.ncbi.nlm.nih.gov/pubmed/29270949</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1055/s-0043-124436" target="_blank" >10.1055/s-0043-124436</a>

Result language

angličtina

Original language name

Clinical perspectives of lithium's neuroprotective effect

Original language description

Evidence for a neuroprotective effect of lithium has accumulated over the last 2 decades, and this phenomenon has been regarded as an important mechanism of lithium action in mood disorders. It has been reflected by an increase in cerebral gray matter volume in lithium-treated subjects and by the favorable influence of lithium on cognitive functions. A neuroprotective effect of lithium also makes this ion a possible candidate for use as a therapeutic drug in neurology, especially in neurodegenerative disorders. In this paper, neurochemical mechanisms of neuroprotective action of lithium will be characterized. A possible association between the effect of lithium on brain structures reflected in neuroimaging studies, as well as on cognitive functions, and its neuroprotective action, will be considered. Data from experimental, epidemiological, and clinical studies have also pointed to an antidementia effect of lithium, bringing about some promise of using lithium in the treatment of mild cognitive impairment and Alzheimer&apos;s disease. The results of attempts of employing lithium in other neurodegenerative disorders will also be discussed.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30215 - Psychiatry

Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Pharmacopsychiatry

ISSN

0176-3679

e-ISSN

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Volume of the periodical

51

Issue of the periodical within the volume

5

Country of publishing house

DE - GERMANY

Number of pages

6

Pages from-to

194-199

UT code for WoS article

000441455000007

EID of the result in the Scopus database

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