Obesity, dyslipidemia and brain age in first-episode psychosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F18%3A43919327" target="_blank" >RIV/00023752:_____/18:43919327 - isvavai.cz</a>
Alternative codes found
RIV/67985807:_____/18:00488005 RIV/00216208:11120/18:43916347
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0022395617312141" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0022395617312141</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jpsychires.2018.02.012" target="_blank" >10.1016/j.jpsychires.2018.02.012</a>
Alternative languages
Result language
angličtina
Original language name
Obesity, dyslipidemia and brain age in first-episode psychosis
Original language description
Introduction Obesity and dyslipidemia may negatively affect brain health and are frequent medical comorbidities of schizophrenia and related disorders. Despite the high burden of metabolic disorders, little is known about their effects on brain structure in psychosis. We investigated, whether obesity or dyslipidemia contributed to brain alterations in first-episode psychosis (FEP). Methods 120 participants with FEP, who were undergoing their first psychiatric hospitalization, had <24 months of untreated psychosis and were 18–35 years old and 114 controls within the same age range participated in the study. We acquired 3T brain structural MRI, fasting lipids and body mass index. We used machine learning trained on an independent sample of 504 controls to estimate the individual brain age of study participants and calculated the BrainAGE score by subtracting the chronological from the estimated brain age. Results In a multiple regression model, the diagnosis of FEP (B = 1.15, SE B = 0.31, p < 0.001) and obesity/overweight (B = 0.92, SE B = 0.35, p = 0.008) were each additively associated with BrainAGE scores (R2 = 0.22, F(3, 230) = 21.92, p < 0.001). BrainAGE scores were highest in participants with FEP and obesity/overweight (3.83 years, 95%CI = 2.35-5.31) and lowest in normal weight controls (−0.27 years, 95%CI = −1.22-0.69). LDL-cholesterol, HDL-cholesterol or triglycerides were not associated with BrainAGE scores. Conclusions Overweight/obesity may be an independent risk factor for diffuse brain alterations manifesting as advanced brain age already early in the course of psychosis. These findings raise the possibility that targeting metabolic health and intervening already at the level of overweight/obesity could slow brain ageing in FEP.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30215 - Psychiatry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Psychiatric Research
ISSN
0022-3956
e-ISSN
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Volume of the periodical
99
Issue of the periodical within the volume
April 2018
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
151-158
UT code for WoS article
000429511200017
EID of the result in the Scopus database
2-s2.0-85042011818