Brain age in early stages of bipolar disorders or schizophrenia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F19%3A43919191" target="_blank" >RIV/00023752:_____/19:43919191 - isvavai.cz</a>

Result on the web

<a href="https://academic.oup.com/schizophreniabulletin/advance-article/doi/10.1093/schbul/sbx172/4767816?searchresult=1" target="_blank" >https://academic.oup.com/schizophreniabulletin/advance-article/doi/10.1093/schbul/sbx172/4767816?searchresult=1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/schbul/sbx172" target="_blank" >10.1093/schbul/sbx172</a>

Result language

angličtina

Original language name

Brain age in early stages of bipolar disorders or schizophrenia

Original language description

BACKGROUND: The greater presence of neurodevelopmental antecedants may differentiate schizophrenia from bipolar disorders (BD). Machine learning/pattern recognition allows us to estimate the biological age of the brain from structural magnetic resonance imaging scans (MRI). The discrepancy between brain and chronological age could contribute to early detection and differentiation of BD and schizophrenia. METHODS: We estimated brain age in 2 studies focusing on early stages of schizophrenia or BD. In the first study, we recruited 43 participants with first episode of schizophrenia-spectrum disorders (FES) and 43 controls. In the second study, we included 96 offspring of bipolar parents (48 unaffected, 48 affected) and 60 controls. We used relevance vector regression trained on an independent sample of 504 controls to estimate the brain age of study participants from structural MRI. We calculated the brain-age gap estimate (BrainAGE) score by subtracting the chronological age from the brain age. RESULTS: Participants with FES had higher BrainAGE scores than controls (F(1, 83) = 8.79, corrected P = 0.008, Cohen&apos;s d = 0.64). Their brain age was on average 2.64 ± 4.15 years greater than their chronological age (matched t(42) = 4.36, P &lt; 0.001). In contrast, participants at risk or in the early stages of BD showed comparable BrainAGE scores to controls (F(2,149) = 1.04, corrected P = 0.70, η2 = 0.01) and comparable brain and chronological age. CONCLUSIONS: Early stages of schizophrenia, but not early stages of BD, were associated with advanced BrainAGE scores. Participants with FES showed neurostructural alterations, which made their brains appear 2.64 years older than their chronological age. BrainAGE scores could aid in early differential diagnosis between BD and schizophrenia.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30215 - Psychiatry

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Schizophrenia Bulletin

ISSN

0586-7614

e-ISSN

—

Volume of the periodical

45

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

190-198

UT code for WoS article

000461523000024

EID of the result in the Scopus database

2-s2.0-85058883008