Brain age in bipolar disorders: effects of lithium treatment
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F19%3A43920093" target="_blank" >RIV/00023752:_____/19:43920093 - isvavai.cz</a>
Result on the web
<a href="https://journals.sagepub.com/doi/10.1177/0004867419857814" target="_blank" >https://journals.sagepub.com/doi/10.1177/0004867419857814</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1177/0004867419857814" target="_blank" >10.1177/0004867419857814</a>
Alternative languages
Result language
angličtina
Original language name
Brain age in bipolar disorders: effects of lithium treatment
Original language description
Objective: Bipolar disorders increase the risk of dementia and show biological and brain alterations, which resemble accelerated aging. Lithium may counter some of these processes and lower the risk of dementia. However, until now no study has specifically investigated the effects of Li on brain age. Methods: We acquired structural magnetic resonance imaging scans from 84 participants with bipolar disorders (41 with and 43 without Li treatment) and 45 controls. We used a machine learning model trained on an independent sample of 504 controls to estimate the individual brain ages of study participants, and calculated BrainAGE by subtracting chronological from the estimated brain age. Results: BrainAGE was significantly greater in non-Li relative to Li or control participants, F(2, 125) = 10.22, p < 0.001, with no differences between the Li treated and control groups. The estimated brain age was significantly higher than the chronological age in the non-Li (4.28 +/- 6.33 years, matched t(42) = 4.43, p < 0.001), but not the Li-treated group (0.48 +/- 7.60 years, not significant). Even Li-treated participants with partial prophylactic treatment response showed lower BrainAGE than the non-Li group, F(1, 64) = 4.80, p = 0.03. Conclusions: Bipolar disorders were associated with greater, whereas Li treatment with lower discrepancy between brain and chronological age. These findings support the neuroprotective effects of Li, which were sufficiently pronounced to affect a complex, multivariate measure of brain structure. The association between Li treatment and BrainAGE was independent of long-term thymoprophylactic response and thus may generalize beyond bipolar disorders, to neurodegenerative disorders.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30215 - Psychiatry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Australian and New Zealand Journal of Psychiatry
ISSN
0004-8674
e-ISSN
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Volume of the periodical
53
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
1179-1188
UT code for WoS article
000497210500007
EID of the result in the Scopus database
2-s2.0-85068365892