Lower serum antibodies against tau protein and heavy neurofilament in Alzheimer disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F18%3A43919424" target="_blank" >RIV/00023752:_____/18:43919424 - isvavai.cz</a>

Result on the web

<a href="https://content.iospress.com/articles/journal-of-alzheimers-disease/jad180039" target="_blank" >https://content.iospress.com/articles/journal-of-alzheimers-disease/jad180039</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3233/JAD-180039" target="_blank" >10.3233/JAD-180039</a>

Result language

angličtina

Original language name

Lower serum antibodies against tau protein and heavy neurofilament in Alzheimer disease

Original language description

Background. Unlike antibodies against beta-amyloid, little is known about serum antibodies to neuron- and disease-specific cytoskeletal proteins in patients with Alzheimer disease (AD). Moreover, fluctuations of these antibodies over time are not known, neither. Patients and methods. Antibodies against three targets (tau, light (NFL) and heavy (NFH) neurofilaments) were measured using ELISA in 100 serum samples from 51 cognitively normal elderly controls (NC) and 49 patients with AD fulfilling NINCDS-ADRDA criteria. We also measured all three anti-neurocytoskeletal antibodies in paired serum samples from 48 NC and 11 AD patients after 562?161 days in NC and after 441?253 days in AD. Results. The AD patients had significantly lower levels of anti-tau antibodies (p = 0.03) and more anti-NFH antibodies (p = 0.005) than those in the control group at baseline. On the contrary, anti-NFL antibodies or total IgG concentrations in serum did not differ. All three antibodies remained stable in both groups except for a selective and significant anti-tau decline in AD patients (p = 0.03). Conclusions. The different responses to these antigens suggest some antibody selectivity in AD. The significant decline was observed for only serum anti-tau antibodies in AD patients over time and it corresponds to lower levels in these patients. Our findings indicate a novel and special feature of disease-relevant antigens and humoral autoimmunity in AD.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/LO1611" target="_blank" >LO1611: Sustainability for The National Institute of Mental Health</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Alzheimer´s Disease

ISSN

1387-2877

e-ISSN

—

Volume of the periodical

64

Issue of the periodical within the volume

3

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

10

Pages from-to

751-760

UT code for WoS article

000437257500006

EID of the result in the Scopus database

2-s2.0-85049687560