Lower Serum Antibodies Against Tau Protein and Heavy Neurofilament in Alzheimer's Disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10376805" target="_blank" >RIV/00216208:11110/18:10376805 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/18:43916903 RIV/00216208:11130/18:10376805 RIV/00064173:_____/18:N0000112 RIV/00064203:_____/18:10376805

Result on the web

<a href="https://doi.org/10.3233/JAD-180039" target="_blank" >https://doi.org/10.3233/JAD-180039</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3233/JAD-180039" target="_blank" >10.3233/JAD-180039</a>

Result language

angličtina

Original language name

Lower Serum Antibodies Against Tau Protein and Heavy Neurofilament in Alzheimer's Disease

Original language description

Background: Unlike antibodies against amyloid-beta, little is known about serum antibodies to neuron-specific cytoskeletal proteins in patients with Alzheimer&apos;s disease (AD). Objective: We aimed to study IgG autoantibodies against tau protein, light (NFL) and heavy subunits (NFH) of neurofilaments in serum of AD patients and elderly controls and to explore the evolution of antineurocytoskeletal antibody levels over time. Methods: Antibodies against three targets (tau, NFL, and NFH) were measured using ELISA in 100 serum samples from 51 cognitively normal elderly controls and 49 patients with AD. Our primary cross-sectional design was further extended to monitor fluctuations over 1-2 years in a subset of individuals. Results: The AD patients had lower levels of anti-tau antibodies (p = 0.03) and even lower anti-NFH antibodies (p = 0.005) than those in the control group at baseline. On the contrary, anti-NFL antibodies or total IgG concentrations in serum did not differ. All three antibodies remained stable in both groups except for a selective and significant anti-tau decline in AD patients (p = 0.03). Conclusions: The different responses to these antigens suggest some antibody selectivity in AD. The significant decline was observed for only serum anti-tau antibodies in AD patients over time and it corresponds to lower anti-tau levels in these patients. Our findings indicate a special feature of disease-relevant antigens and humoral autoimmunity in AD.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Alzheimer&apos;s Disease

ISSN

1387-2877

e-ISSN

—

Volume of the periodical

64

Issue of the periodical within the volume

3

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

10

Pages from-to

751-760

UT code for WoS article

000437257500006

EID of the result in the Scopus database

2-s2.0-85049687560