Investigating polygenic burden in age at disease onset in bipolar disorder: Findings from an international multicentric study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F19%3A43919501" target="_blank" >RIV/00023752:_____/19:43919501 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/19:43916850

Result on the web

<a href="https://onlinelibrary.wiley.com/doi/abs/10.1111/bdi.12659" target="_blank" >https://onlinelibrary.wiley.com/doi/abs/10.1111/bdi.12659</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/bdi.12659" target="_blank" >10.1111/bdi.12659</a>

Result language

angličtina

Original language name

Investigating polygenic burden in age at disease onset in bipolar disorder: Findings from an international multicentric study

Original language description

OBJECTIVES: Bipolar disorder (BD) with early disease onset is associated with an unfavorable clinical outcome and constitutes a clinically and biologically homogenous subgroup within the heterogeneous BD spectrum. Previous studies have found an accumulation of early age at onset (AAO) in BD families and have therefore hypothesized that there is a larger genetic contribution to the early-onset cases than to late onset BD. To investigate the genetic background of this subphenotype, we evaluated whether an increased polygenic burden of BD- and schizophrenia (SCZ)-associated risk variants is associated with an earlier AAO in BD patients. METHODS: A total of 1995 BD type 1 patients from the Consortium of Lithium Genetics (ConLiGen), PsyCourse and Bonn-Mannheim samples were genotyped and their BD and SCZ polygenic risk scores (PRSs) were calculated using the summary statistics of the Psychiatric Genomics Consortium as a training data set. AAO was either separated into onset groups of clinical interest (childhood and adolescence [≤18 years] vs adulthood [&gt;18 years]) or considered as a continuous measure. The associations between BD- and SCZ-PRSs and AAO were evaluated with regression models. RESULTS: BD- and SCZ-PRSs were not significantly associated with age at disease onset. Results remained the same when analyses were stratified by site of recruitment. CONCLUSIONS: The current study is the largest conducted so far to investigate the association between the cumulative BD and SCZ polygenic risk and AAO in BD patients. The reported negative results suggest that such a polygenic influence, if there is any, is not large, and highlight the importance of conducting further, larger scale studies to obtain more information on the genetic architecture of this clinically relevant phenotype.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30215 - Psychiatry

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bipolar Disorders

ISSN

1398-5647

e-ISSN

—

Volume of the periodical

21

Issue of the periodical within the volume

1

Country of publishing house

DK - DENMARK

Number of pages

8

Pages from-to

68-75

UT code for WoS article

000459791000009

EID of the result in the Scopus database

2-s2.0-85062093950