Characterisation of age and polarity at onset in bipolar disorder

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F21%3A43920654" target="_blank" >RIV/00023752:_____/21:43920654 - isvavai.cz</a>

Result on the web

<a href="https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/characterisation-of-age-and-polarity-at-onset-in-bipolar-disorder/DBFE4929435DBD6D75BC546201BC4BA1" target="_blank" >https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/characterisation-of-age-and-polarity-at-onset-in-bipolar-disorder/DBFE4929435DBD6D75BC546201BC4BA1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1192/bjp.2021.102" target="_blank" >10.1192/bjp.2021.102</a>

Result language

angličtina

Original language name

Characterisation of age and polarity at onset in bipolar disorder

Original language description

Background: Studying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening tools. Aims: To examine the genetic architecture of AAO and PAO and their association with bipolar disorder disease characteristics. Method: Genome-wide association studies (GWASs) and polygenic score (PGS) analyses of AAO (n = 12 977) and PAO (n = 6773) were conducted in patients with bipolar disorder from 34 cohorts and a replication sample (n = 2237). The association of onset with disease characteristics was investigated in two of these cohorts. Results: Earlier AAO was associated with a higher probability of psychotic symptoms, suicidality, lower educational attainment, not living together and fewer episodes. Depressive onset correlated with suicidality and manic onset correlated with delusions and manic episodes. Systematic differences in AAO between cohorts and continents of origin were observed. This was also reflected in single-nucleotide variant-based heritability estimates, with higher heritabilities for stricter onset definitions. Increased PGS for autism spectrum disorder (β = −0.34 years, s.e. = 0.08), major depression (β = −0.34 years, s.e. = 0.08), schizophrenia (β = −0.39 years, s.e. = 0.08), and educational attainment (β = −0.31 years, s.e. = 0.08) were associated with an earlier AAO. The AAO GWAS identified one significant locus, but this finding did not replicate. Neither GWAS nor PGS analyses yielded significant associations with PAO. Conclusions: AAO and PAO are associated with indicators of bipolar disorder severity. Individuals with an earlier onset show an increased polygenic liability for a broad spectrum of psychiatric traits. Systematic differences in AAO across cohorts, continents and phenotype definitions introduce significant heterogeneity, affecting analyses.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30215 - Psychiatry

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

British Journal of Psychiatry

ISSN

0007-1250

e-ISSN

—

Volume of the periodical

219

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

659-669

UT code for WoS article

000723150400009

EID of the result in the Scopus database

2-s2.0-85114705031