Neurobiology and therapeutic applications of neurotoxins targeting transmitter release
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F19%3A43919562" target="_blank" >RIV/00023752:_____/19:43919562 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/19:43917811
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0163725818301542?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0163725818301542?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.pharmthera.2018.08.016" target="_blank" >10.1016/j.pharmthera.2018.08.016</a>
Alternative languages
Result language
angličtina
Original language name
Neurobiology and therapeutic applications of neurotoxins targeting transmitter release
Original language description
Synaptic transmission is a fundamental neurobiological process enabling exchange of signals between neurons as well as neurons and their non-neuronal effectors. The complex molecular machinery of the synaptic vesicle cycle and transmitter release has emerged and developed in the course of the evolutionary race, to ensure adaptive gain and survival of the fittest. In parallel, a generous arsenal of biomolecules and neuroactive peptides have co-evolved, which selectively target the transmitter release machinery, with the aim of subduing natural rivals or neutralizing prey. With advances in neuropharmacology and quantitative biology, neurotoxins targeting presynaptic mechanisms have attracted major interest, revealing considerable potential as carriers of molecular cargo and probes for meddling synaptic transmission mechanisms for research and medical benefit. In this review, we investigate and discuss key facets employed by the most prominent bacterial and animal toxins targeting the presynaptic secretory machinery.We explore the cellular basis and molecular grounds for their tremendous potency and selectivity, with effects on a wide range of neural functions. Finally, we consider the emerging preclinical and clinical data advocating the use of active ingredients of neurotoxins for the advancement of molecular medicine and development of restorative therapies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pharmacology & Therapeutics
ISSN
0163-7258
e-ISSN
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Volume of the periodical
193
Issue of the periodical within the volume
January
Country of publishing house
US - UNITED STATES
Number of pages
21
Pages from-to
135-155
UT code for WoS article
000456227400011
EID of the result in the Scopus database
2-s2.0-85053120552