A systematic review on donepezil-based derivatives as potential cholinesterase inhibitors for Alzheimer’s disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F19%3A43919679" target="_blank" >RIV/00023752:_____/19:43919679 - isvavai.cz</a>
Result on the web
<a href="http://www.eurekaselect.com/162233/article" target="_blank" >http://www.eurekaselect.com/162233/article</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/0929867325666180517094023" target="_blank" >10.2174/0929867325666180517094023</a>
Alternative languages
Result language
angličtina
Original language name
A systematic review on donepezil-based derivatives as potential cholinesterase inhibitors for Alzheimer’s disease
Original language description
Alzheimer’s disease (AD) is a multifactorial progressive neurodegenerative disorder characterized by memory loss, disorientation, and gradual deterioration of intellectual capacity. Its etiology has not been elucidated yet. To date, only one therapeutic approach has been approved for the treatment of AD. The pharmacotherapy of AD has relied on noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist - memantine, and acetylcholinesterase (AChE) inhibitors (AChEIs) - tacrine, donepezil, rivastigmine and galantamine. Donepezil was able to ameliorate the symptoms related to AD mainly via AChE, but also through reduction of β-amyloid burden. This review presents the overview of donepezilrelated compounds as potential anti-AD drugs developed on the basis of cholinergic hypothesis to act as solely AChE and butyrylcholinesterase (BChE) inhibitors.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/LO1611" target="_blank" >LO1611: Sustainability for The National Institute of Mental Health</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Medicinal Chemistry
ISSN
0929-8673
e-ISSN
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Volume of the periodical
26
Issue of the periodical within the volume
30
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
23
Pages from-to
5625-5648
UT code for WoS article
000493956000003
EID of the result in the Scopus database
2-s2.0-85075054706