Pyramidal system involvement in progressive supranuclear palsy - a clinicopathological correlation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F19%3A43919828" target="_blank" >RIV/00023752:_____/19:43919828 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21340/19:00335995 RIV/00216208:11110/19:10392928 RIV/00216208:11120/19:43917826 RIV/00064173:_____/19:N0000014 and 2 more

Result on the web

<a href="https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-019-1270-1#Abs1" target="_blank" >https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-019-1270-1#Abs1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12883-019-1270-1" target="_blank" >10.1186/s12883-019-1270-1</a>

Result language

angličtina

Original language name

Pyramidal system involvement in progressive supranuclear palsy - a clinicopathological correlation

Original language description

Background: We aimed to produce a detailed neuropathological analysis of pyramidal motor system pathology and provide its clinical pathological correlation in cases with definite progressive supranuclear palsy (PSP). Methods: Pyramidal motor system pathologies were analyzed in 18 cases with neuropathologically confirmed PSP. Based on a retrospective clinical analysis, cases were subtyped according to Movement Disorder Society criteria for clinical diagnosis of PSP as probable, possible or suggestive of PSP with Richardson’s syndrome (n = 10), PSP with predominant corticobasal syndrome (n = 3), PSP with predominant parkinsonism (n = 3), PSP with predominant speech/language disorder (n = 1), and PSP with progressive gait freezing (n = 1). Clinical manifestations of motor neuron involvement (pseudobulbar or bulbar signs and spasticity) were retrospectively assessed semiquantitatively. Neuropathologically, hyperphosphorylated tau-related pyramidal motor system neuronal, neuritic, and glial pathology using anti-tau AT8 clone immunohistochemistry, was also evaluated. Results: Clinical manifestations of pyramidal motor system involvement were found in patients with different PSP subtypes. A statistically significant higher load of tau pathology was found in the pyramidal system in PSP-Richardson’s syndrome compared to other PSP subtypes (p = 0.016); however, there was no significant correlation between pyramidal system tau pathology and related motor clinical symptoms. Conclusions: Tau pathology in the spinal cord and pyramidal motor system structures is very common in progressive supranuclear palsy and may neuropathologically supplement the distinction between classic Richardson’s syndrome from other progressive supranuclear palsy subtypes.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30210 - Clinical neurology

Project

<a href="/en/project/LO1611" target="_blank" >LO1611: Sustainability for The National Institute of Mental Health</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BMC Neurology

ISSN

1471-2377

e-ISSN

—

Volume of the periodical

19

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

"Article number 42"

UT code for WoS article

000462234800001

EID of the result in the Scopus database

2-s2.0-85063275822