The effect of the cannabinoid receptor agonist and antagonist on the light-induced changes in the suprachiasmatic nucleus of rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F19%3A43919848" target="_blank" >RIV/00023752:_____/19:43919848 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/19:10397682
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0304394019301788?via%3Dihub#" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0304394019301788?via%3Dihub#</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.neulet.2019.03.022" target="_blank" >10.1016/j.neulet.2019.03.022</a>
Alternative languages
Result language
angličtina
Original language name
The effect of the cannabinoid receptor agonist and antagonist on the light-induced changes in the suprachiasmatic nucleus of rats
Original language description
The CB1 cannabinoid receptors have been found in the rodent suprachiasmatic nucleus, and their activation suppresses the light-induced phase shift in locomotor rhythmicity of mice and hamsters. Here, we show that the CB1 receptor agonist CP55940 significantly attenuates the light-induced phase delay in rats as well. Furthermore, it blocks the light induction of c-Fos and light-induced downregulation of pERK1/2 in the SCN, and the CB1 antagonist AM251 prevents the photic induction of pERK1/2 and reduces pGSK3β after photic stimulation. Our data suggest that the modulation of the cannabinoid receptor activity may affect the photic entrainment via the setting of the SCN sensitivity to light.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neuroscience Letters
ISSN
0304-3940
e-ISSN
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Volume of the periodical
703
Issue of the periodical within the volume
June
Country of publishing house
IE - IRELAND
Number of pages
4
Pages from-to
49-52
UT code for WoS article
000470342000009
EID of the result in the Scopus database
2-s2.0-85063041374